EFEK GAMBIR (UNCARIA GAMBIR/HUNTER ROXB) TERHADAP AKTIVITAS LOKOMOTOR DAN NEUROKOGNITIF PADA TIKUS BETINA MODEL ALZHEIMER

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   GAMBIER (UNCARIA GAMBIR/HUNTER ROXB) ADMINISTRATION IMPROVES LOCOMOTOR ACTIVITIES AND NEUROCOGNITIVE IMPAIRMENT IN ALZHEIMER’S MODEL FEMALE RATABSTRACTIntroduction: Locomotor activity (LA) disturbance and neurocognitive impairment in Alzheimer’s disease (AD) mechanism was suggested through many ways; one of them is the induction of oxidative stress that corrupted hippocampus cortex.Aims: The aim of this study was to determine whether or not the administration of potent antioxidant gambier ca- techin (GDC) to AD model female rat improves locomotion (LA) and cognitive function (CF).Methods: This experimental research was carried out to 12-week-old 25 Sprague dawley AD model female rats with proven CF impairment. Subjects were divided into 5 groups; control negative (N) and positive (P), and catechin groups (AC1, AC2, and AC3), which treated with oral GDC, 20mg, 40mg, and 60mg/200gBW, respectively, for four weeks. LA (total arm entered) and spatial memory were measured before and after treatment using Y-maze based on spontaneous alternation of each groups.Results: There were significant alteration  differences in AC2 and AC3 groups (69% and 2%) after 40mg and 60mg/299gBW treatment after 4 weeks.Discussion: 40mg and 60mg/200gBW oral GDC treatment for four weeks improves spatial memory function on AD model female rat, however no significant changes on locomotor activity.Keywords: Alzheimer, catechin, cognitive, gambier, locomotor, ratABSTRAKPendahuluan: Gangguan aktivitas lokomotor dan penurunan neurokognitif pada penyakit Alzheimer diperkirakan terjadi melalui beberapa jalan, salah satunya stres oksidatif yang merusak korteks hipokampus.Tujuan: Mengetahui efek pemberian antioksidan kuat katekin gambir (DKG) pada tikus betina model Alzheimer terhadap pergerakan (aktivitas lokomotor) dan fungsi kognitif.Metode: Penelitian eksperimental terhadap 25 ekor tikus model Alzheimer Sprague dawley betina usia 12 minggu yang sudah terbukti mengalami gangguan fungsi kognitif. Tikus dibagi menjadi 5 kelompok, yaitu kontrol negatif (N) dan positif (P), serta kelompok katekin (AC1, AC2, dan AC3) yang diberi DKG oral dengan dosis masing-masing 20mg, 40mg, dan 60mg/200gBB selama empat minggu. Dilakukan penilaian uji lokomotor dan memori spasial menggunakan Y-maze pada awal dan setelah perlakuan berdasarkan perbedaan alternasi spontan dari setiap kelompok.Hasil: Terdapat perbedaan alternasi yang signifikan pada kelompok AC2 dan AC3 (69% dan 82%) pascapemberian DKG oral 40mg dan 60mg/200gBB selama empat minggu.Diskusi: Pemberian DKG oral 40mg dan 60mg/200gBB selama empat minggu memperbaiki fungsi memori spasial pada tikus betina model Alzheimer, namun tidak bermakna pada aktivitas lokomotor.Kata kunci: Alzheimer, gambir, katekin, kognitif, lokomotor, tikus